PathoYeastract (Pathogenic Yeast Search for Transcriptional Regulators And Consensus Tracking) is a curated repository of all known regulatory associations between transcription factors (TF) and target genes in pathogenic Candida species, based on hundreds of bibliographic references. It currently provides information for the five most prevalent of pathogenic yeasts, C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, and C. auris.

Facilities are also provided to enable the exploitation of the gathered data when solving a number of biological questions, as exemplified in the Tutorial. PathoYeastract allows the identification of documented or potential transcription regulators of a given gene and of documented or potential regulons for each transcription factor. It also renders possible the comparison between DNA motifs and the transcription factor binding sites described in the literature. Finally, the system provides a useful tool for grouping a list of genes (for instance a set of genes with similar expression profiles as revealed by microarray or RNA-seq analysis) based on their regulatory associations with known transcription factors. All analysis can be carried out based on the existing data for the Candida species the user is working on or based on transcription associations occurring among orthologous genes and TFs in the remaining Candida species or in the model yeast Saccharomyces cerevisiae.

	Enter Candida glabrata		Enter Candida albicans
	Enter Candida tropicalis		Enter Candida parapsilosis
	Enter Candida auris

M.C. Teixeira, R. Viana, M. Palma, J. Oliveira, M. Galocha, M.N. Mota, D. Couceiro, M.G. Pereira, M. Antunes, I.V. Costa, P. Pais, C. Parada, C. Chaouiya, I. Sá-Correia, P.T. Monteiro (2023)
YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis
Nucleic Acids Research, 51(D1):D785-D791
doi:10.1093/nar/gkac1041