C.albicans - PathoYeastract

Regulation Reference(s)

The PathoYeastract team, is actively curating each regulation evidence code, association type and environmental condition.

Transcription Factor	Target ORF/Genes	References	Evidence Code	Evidence Experiment	Association Type	Strain	Environmental Group	Environmental Condition	Log2FC
Tac1p	C3_04890W_A	PubMed Coste AT et al., Eukaryotic cell, 2004 Dec;3(6):1639-52	Direct	EMSA	N/A	SC5314	Unstressed log-phase growth (control)	Control	N/A
			Indirect	Northern blot - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazine	N/A
			Indirect	lacZ - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazine	N/A
			Indirect	Microarray analysis - WT vs TF Deletion	Positive	CAF2-1	Stress	Each strain was pregrown overnight in 5 ml of YEPD with constant agitation at 30°C. Strains were exposed for 20 min to 10 μg of fluphenazine.	N/A
		PubMed Coste A et al., Eukaryotic cell, 2007 Oct;6(10):1889-904	Indirect	Western blot - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazine	N/A
		PubMed Znaidi S et al., Molecular microbiology, 2007 Oct;66(2):440-52	Indirect	Northern blot - wt vs TF mutant	Positive	SC5314	Unstressed log-phase growth (control)	Control	N/A
		PubMed Liu TT et al., Eukaryotic cell, 2007 Nov;6(11):2122-38	Direct	Chip-on-chip	N/A	SC5314	Unstressed log-phase growth (control)	Control	N/A
		PubMed MacCallum DM et al., Antimicrobial agents and chemotherapy, 2010 Apr;54(4):1476-83	Indirect	Northern blot - wt vs TF mutant	Positive	SC5314	Unstressed log-phase growth (control)	Control	N/A
		PubMed Sasse C et al., PloS one, 2011;6(9):e25623	Indirect	Western blot - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazine	N/A
		PubMed Lohberger A et al., Eukaryotic cell, 2014 Jan;13(1):127-42	Indirect	RT-PCR - wt vs TF mutant	Positive	SC5314	Unstressed log-phase growth (control)	Control	N/A
			Indirect	Western blot - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazine	N/A
		PubMed Liu Z et al., Antimicrobial agents and chemotherapy, 2017 Nov;61(11):	Direct	ChIP	N/A	SC5314	Unstressed log-phase growth (control)	YPD	N/A
			Direct	ChIP	N/A	SC5314	Stress	10 mg/L fluphenazine during 15 min	N/A
			Direct	ChIP	Positive	SC5314	Stress	Fluphenazinee stress (10 microg/mL for 15 min)	N/A
			Direct	RT-PCR - wt vs mutant promoter sequence	Positive	SC5314	Stress	10 mg/L fluphenazine	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SC5314	Unstressed log-phase growth (control)	YPD	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SC5314	Stress	20 mg/L fluphenazine during 30 min	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazine stress	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SC5314	Unstressed log-phase growth (control)	Control, YPD, 30.C	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SC5314	Stress	Fluphenazinee stress (20 microg/mL for 30 min)	N/A
			Indirect	RT-PCR - wt vs TF overexpression	Positive	SC5314	Unstressed log-phase growth (control)	YPD	N/A
		PubMed Liu Z et al., Antimicrobial agents and chemotherapy, 2018 Nov;62(11):	Direct	ChIP	N/A	SN152	Unstressed log-phase growth (control)	Control	N/A
			Direct	ChIP	N/A	SN152	Stress	Farnesol stess (50 microM)	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SN152	Stress	1-Dodecanol stress (50 microM)	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SN152	Stress	Farnesol stess (50 microM)	N/A
			Indirect	RT-PCR - wt vs TF mutant	Positive	SN152	Stress	Fluphenazinee stress (25 microM)	N/A
		PubMed Liu JY et al., Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020 Dec;51(4):1553-1561	Indirect	RT-PCR - wt vs TF mutant	Positive	SN152	Unstressed log-phase growth (control)	Control, YPD, 30.C	N/A
			Indirect	Western blot - wt vs TF mutant	Positive	SN152	Unstressed log-phase growth (control)	Control, YPD, 30.C	N/A
			Indirect	Western blot - wt vs TF mutant	Positive	SN152	Stress	Fluphenazine stress (10 mg/L for 6h)	N/A
		PubMed Lim WJ et al., Microbiology (Reading, England), 2025 Sep;171(9):	Indirect	RNA-seq analysis - TF GOF vs WT	Positive	CC16	Unstressed log-phase growth (control)	Grown overnight in YEPD broth in a shaking incubator at 200 rpm, cultures inoculated to an OD600 = 0.1 and incubated at 37 °C with 200 rpm shaking until an OD600=0.8. Transcription factor gene gain-of-function in a Δtlo strain.	4.23921811643307