S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ntg1p
Description	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
GO Terms: Biological Process	level 4: cellular response to oxidative stress level 5: DNA repair level 6: nucleotide-excision repair level 6: base-excision repair level 6: base-excision repair, AP site formation level 8: positive regulation of mitochondrial DNA replication
GO Terms: Molecular Function	level 1: catalytic activity level 3: DNA binding level 4: DNA N-glycosylase activity level 4: class I DNA-(apurinic or apyrimidinic site) endonuclease activity level 6: oxidized purine nucleobase lesion DNA N-glycosylase activity level 6: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity level 6: DNA-(apurinic or apyrimidinic site) endonuclease activity
GO Terms: Cellular Component	level 3: mitochondrion level 4: nucleus
External source	Open in SGD