S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Drs2p
Description	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease
GO Terms: Biological Process	level 4: post-Golgi vesicle-mediated transport level 4: endocytic recycling level 5: endocytosis level 5: phospholipid transport level 5: phospholipid translocation level 6: aminophospholipid translocation
GO Terms: Molecular Function	level 2: ATPase-coupled intramembrane lipid carrier activity level 2: ATP hydrolysis activity level 3: nucleotide binding level 4: phosphatidylserine floppase activity level 4: phosphatidylcholine flippase activity level 4: ATP binding level 5: phosphatidylserine flippase activity level 5: phosphatidylethanolamine flippase activity level 6: magnesium ion binding
GO Terms: Cellular Component	level 2: membrane level 3: plasma membrane level 3: endoplasmic reticulum level 3: Golgi apparatus level 4: trans-Golgi network level 4: endosome membrane level 4: Cdc50p-Drs2p complex
External source	Open in SGD