S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cdc7p
Description	Ser/Thr kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45p to drive assembly of the pre-IC and the replicative CMG helicase (Cdc45-MCM-GINS); regulates pre-meiotic DNA replication, meiotic DSB formation, monopolar attachment of homologs during MI by recruiting monopolin to kinetochores, and regulation of middle meiotic genes including NDT80; complemented by co-expression of human CDC7 and DBF4
GO Terms: Biological Process	level 2: signal transduction level 3: protein-containing complex localization level 3: premeiotic DNA replication level 4: mitotic DNA replication checkpoint signaling level 4: mitotic DNA replication preinitiation complex assembly level 4: positive regulation of spindle attachment to meiosis I kinetochore level 5: positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination level 5: positive regulation of protein localization to kinetochore level 6: DNA replication initiation level 7: positive regulation of meiosis I level 8: double-strand break repair via break-induced replication level 8: negative regulation of exit from mitosis
GO Terms: Molecular Function	level 3: protein kinase activity level 4: protein serine/threonine kinase activity level 4: protein serine kinase activity level 4: ATP binding
GO Terms: Cellular Component	level 2: chromatin level 2: cytoplasm level 3: chromosome, centromeric region level 3: Dbf4-dependent protein kinase complex level 4: nucleus
External source	Open in SGD