S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sir2p
Description	Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy
GO Terms: Biological Process	level 3: establishment of protein-containing complex localization to telomere level 3: regulation of DNA stability level 3: sister chromatid cohesion level 4: regulation of mating type switching level 4: chromatin organization level 4: DNA damage response level 5: telomere tethering at nuclear periphery level 6: rDNA heterochromatin formation level 6: NAD+ biosynthetic process level 7: double-strand break repair via nonhomologous end joining level 7: subtelomeric heterochromatin formation level 7: NAD+ biosynthetic process via the salvage pathway level 7: silent mating-type cassette heterochromatin formation level 8: negative regulation of DNA replication level 8: negative regulation of DNA recombination level 9: negative regulation of DNA amplification level 9: negative regulation of DNA-templated transcription
GO Terms: Molecular Function	level 3: nucleosome binding level 3: transcription corepressor activity level 4: NAD-dependent protein lysine deacetylase activity level 5: NAD+ binding level 5: histone deacetylase activity, NAD-dependent level 6: histone H4K16 deacetylase activity, NAD-dependent level 6: histone H3K14 deacetylase activity, NAD-dependent level 6: DNA replication origin binding level 6: histone H3K9 deacetylase activity, NAD-dependent level 7: zinc ion binding
GO Terms: Cellular Component	level 2: cytosol level 2: chromatin level 3: chromosome, telomeric region level 3: heterochromatin level 3: chromatin silencing complex level 4: nucleus level 4: nucleolus level 4: RENT complex level 5: nuclear lumen
External source	Open in SGD