S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sir4p
Description	SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some SIR4 alleles prolong lifespan; required for Ku-mediated telomerase recruitment, telomere lengthening, and telomere hypercluster formation in quiescent yeast cells
GO Terms: Biological Process	level 3: establishment of protein-containing complex localization to telomere level 5: telomere tethering at nuclear periphery level 6: positive regulation of heterochromatin formation level 7: double-strand break repair via nonhomologous end joining level 7: silent mating-type cassette heterochromatin formation level 7: subtelomeric heterochromatin formation
GO Terms: Molecular Function	level 1: molecular adaptor activity level 3: nucleosome binding level 4: double-stranded DNA binding
GO Terms: Cellular Component	level 3: chromosome, telomeric region level 3: chromatin silencing complex level 4: nucleus
External source	Open in SGD