S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Dot1p
Description	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response; single DOT1 gene produces two Dot1p isoforms from alternative translation start sites as a result of leaky scanning by the ribosome
GO Terms: Biological Process	level 4: regulation of cell cycle level 4: meiotic recombination checkpoint signaling level 5: DNA repair level 5: DNA damage tolerance level 5: nucleosome assembly level 5: DNA damage checkpoint signaling level 5: mitotic G1 DNA damage checkpoint signaling level 5: mitotic intra-S DNA damage checkpoint signaling level 6: nucleotide-excision repair level 6: recombinational repair level 7: global genome nucleotide-excision repair level 7: subtelomeric heterochromatin formation level 8: negative regulation of heterochromatin formation level 8: double-strand break repair via break-induced replication
GO Terms: Molecular Function	level 3: histone binding level 5: histone H3K79 methyltransferase activity level 6: histone H3K79 trimethyltransferase activity
GO Terms: Cellular Component	level 3: chromosome, telomeric region level 3: nucleosome level 4: nucleus
External source	Open in SGD