S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Rsp5p
Description	NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome
GO Terms: Biological Process	level 3: cellular response to stress level 4: free ubiquitin chain polymerization level 4: cellular response to heat level 4: chromatin organization level 4: late endosome to vacuole transport via multivesicular body sorting pathway level 4: regulation of protein localization level 5: ribophagy level 5: ubiquitin-dependent endocytosis level 5: cellular response to amino acid stimulus level 5: cellular response to L-arginine level 5: regulation of nitrogen utilization level 5: mitochondrion organization level 5: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway level 5: regulation of actin cytoskeleton organization level 5: positive regulation of endocytosis level 6: positive regulation of receptor-mediated endocytosis level 6: protein quality control for misfolded or incompletely synthesized proteins level 6: regulation of mRNA export from nucleus level 6: regulation of tRNA export from nucleus level 7: poly(A)+ mRNA export from nucleus level 7: ubiquitin-dependent protein catabolic process level 7: proteasome-mediated ubiquitin-dependent protein catabolic process level 7: regulation of ergosterol biosynthetic process level 7: regulation of ribosomal large subunit export from nucleus level 7: regulation of rRNA processing level 7: regulation of ubiquinone biosynthetic process level 8: mitochondria-associated ubiquitin-dependent protein catabolic process level 8: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway level 8: positive regulation of fatty acid biosynthetic process level 8: regulation of tRNA processing level 8: regulation of dolichyl monophosphate biosynthetic process level 9: protein ubiquitination level 9: positive regulation of proteasomal ubiquitin-dependent protein catabolic process level 10: positive regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 4: ubiquitin binding level 4: ubiquitin-protein transferase activity level 5: ubiquitin protein ligase activity level 5: phosphatidylinositol binding level 6: ubiquitin-ubiquitin ligase activity
GO Terms: Cellular Component	level 2: cytoplasm level 2: cytosol level 3: plasma membrane level 3: cellular bud tip level 3: actin cortical patch level 3: ubiquitin ligase complex level 3: mitochondrion level 3: Golgi apparatus level 4: nucleus level 4: endosome membrane
External source	Open in SGD