S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Grx4p
Description	Glutathione-dependent oxidoreductase and glutathione S-transferase; hydroperoxide/superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx3p and Grx5p; protects cells from oxidative damage with GRX3 and GRX5; with Grx3p, promotes dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx3p in Sir2p deglutathionylation, restoring deacetylase activity after disulfide stress
GO Terms: Biological Process	level 3: actin cytoskeleton organization level 4: intracellular iron ion homeostasis level 4: cellular response to oxidative stress
GO Terms: Molecular Function	level 4: glutathione transferase activity level 4: disulfide oxidoreductase activity level 5: 2 iron, 2 sulfur cluster binding level 5: RNA polymerase II-specific DNA-binding transcription factor binding
GO Terms: Cellular Component	level 2: iron-sulfur cluster assembly complex level 2: cytosol level 4: nucleus
External source	Open in SGD