S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Eco1p
Description	Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress
GO Terms: Biological Process	level 4: mitotic sister chromatid cohesion level 4: mitotic chromosome condensation level 4: establishment of mitotic sister chromatid cohesion level 4: establishment of meiotic sister chromatid cohesion level 5: chromosome organization level 5: chromatin looping level 5: DNA repair level 6: double-strand break repair level 6: tRNA gene clustering level 6: telomere organization level 6: DNA replication level 8: internal peptidyl-lysine acetylation
GO Terms: Molecular Function	level 5: protein-lysine-acetyltransferase activity level 5: acetyltransferase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 2: chromatin level 2: cytoplasm level 3: nuclear replication fork level 4: nucleus
External source	Open in SGD