S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Vps45p
Description	Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; mutation in human VPS45 is associated with congenital neutropenia and primary myelofibrosis of infancy
GO Terms: Biological Process	level 2: vesicle-mediated transport level 3: cytoplasm to vacuole targeting by the Cvt pathway level 4: Golgi vesicle fusion to target membrane level 4: intracellular protein transport level 5: protein targeting to vacuole level 5: Golgi to endosome transport level 5: Golgi to vacuole transport level 5: vacuole organization level 5: vacuolar acidification level 5: regulation of vesicle fusion level 6: positive regulation of SNARE complex assembly level 6: vacuole inheritance
GO Terms: Molecular Function	level 3: SNARE binding
GO Terms: Cellular Component	level 2: cytosol level 2: cytoplasm level 3: SNARE complex level 3: Golgi apparatus level 4: bounding membrane of organelle level 4: Golgi membrane level 4: vacuolar membrane
External source	Open in SGD