S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Pmr1p
Description	High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant
GO Terms: Biological Process	level 4: macroautophagy level 5: intracellular manganese ion homeostasis level 5: calcium ion transmembrane transport level 5: manganese ion transmembrane transport level 5: intracellular calcium ion homeostasis level 7: calcium ion transport level 8: manganese ion transport
GO Terms: Molecular Function	level 2: ATP hydrolysis activity level 3: nucleotide binding level 3: ATPase-coupled monoatomic cation transmembrane transporter activity level 4: P-type manganese transporter activity level 4: P-type ion transporter activity level 4: P-type calcium transporter activity level 4: ATP binding level 6: manganese ion transmembrane transporter activity level 6: calcium ion binding
GO Terms: Cellular Component	level 2: endomembrane system level 2: membrane level 2: cytoplasm level 3: endoplasmic reticulum level 3: plasma membrane level 4: Golgi membrane
External source	Open in SGD