S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Xrn1p
Description	Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing (P) bodies involved in mRNA decay; enters the nucleus and positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and turnover of tRNA introns; negative regulator of autophagy; activated by the scavenger decapping enzyme Dcs1p; expression regulated by Ash1p in rich conditions
GO Terms: Biological Process	level 3: translational initiation level 5: cellular response to nitrogen starvation level 5: mRNA destabilization level 5: rRNA processing level 5: sno(s)RNA processing level 7: rRNA catabolic process level 7: tRNA decay level 7: NAD-cap decapping level 7: regulation of telomere maintenance level 8: nonfunctional rRNA decay level 8: negative regulation of macroautophagy level 8: nuclear-transcribed mRNA catabolic process level 9: traversing start control point of mitotic cell cycle level 9: nuclear-transcribed mRNA catabolic process, no-go decay level 9: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay level 10: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay level 11: positive regulation of transcription initiation by RNA polymerase II level 11: positive regulation of transcription elongation by RNA polymerase II
GO Terms: Molecular Function	level 2: nucleic acid binding level 2: chromatin binding level 3: RNA binding level 4: mRNA binding level 4: exonuclease activity level 4: eukaryotic initiation factor 4G binding level 5: 5'-3' exonuclease activity level 6: 5'-3' RNA exonuclease activity
GO Terms: Cellular Component	level 2: perinuclear region of cytoplasm level 2: cytoplasm level 3: eisosome membrane domain/MCC level 4: cytoplasmic stress granule level 4: nucleus level 4: P-body
External source	Open in SGD