S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Spt16p
Description	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; specifically required for diauxic shift-induced H2B deposition onto rDNA genes; mutations cause reduced nucleosome occupancy over highly transcribed regions; coregulates transcription with Mot1p through preinitiation complex assembly and nucleosome organization
GO Terms: Biological Process	level 4: chromatin organization level 5: nucleosome assembly level 6: regulation of sister chromatid cohesion level 6: epigenetic regulation of gene expression level 6: transcription elongation-coupled chromatin remodeling level 7: transcription by RNA polymerase II level 7: positive regulation of RNA polymerase II transcription preinitiation complex assembly level 7: DNA-templated DNA replication level 8: transcription initiation-coupled chromatin remodeling level 11: positive regulation of transcription initiation by RNA polymerase II
GO Terms: Molecular Function	level 2: chromatin binding level 2: protein binding level 3: nucleosome binding level 3: histone binding level 4: H2A-H2B histone complex chaperone activity
GO Terms: Cellular Component	level 2: chromatin level 3: FACT complex level 4: nucleus level 4: chromosome
External source	Open in SGD