S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Bub1p
Description	Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication
GO Terms: Biological Process	level 4: mitotic spindle assembly checkpoint signaling level 4: macroautophagy level 4: sister chromatid biorientation level 5: meiotic sister chromatid cohesion, centromeric level 7: protein localization to kinetochore level 8: double-strand break repair via break-induced replication
GO Terms: Molecular Function	level 2: protein binding level 3: protein kinase activity level 4: protein serine kinase activity level 4: protein serine/threonine kinase activity level 4: ATP binding
GO Terms: Cellular Component	level 1: protein-containing complex level 3: kinetochore level 4: nucleus level 4: condensed chromosome, centromeric region
External source	Open in SGD