S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Spo11p
Description	Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11
GO Terms: Biological Process	level 3: meiotic DNA double-strand break processing level 3: reciprocal meiotic recombination level 4: meiotic DNA double-strand break formation level 4: meiosis I level 4: homologous chromosome pairing at meiosis level 4: synaptonemal complex assembly level 5: DNA metabolic process
GO Terms: Molecular Function	level 1: catalytic activity level 2: chromatin binding level 3: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity level 3: DNA binding level 4: DNA end binding level 4: ATP binding
GO Terms: Cellular Component	level 3: site of double-strand break level 4: nucleus level 4: chromosome level 5: nuclear chromosome level 5: condensed nuclear chromosome
External source	Open in SGD