S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mtr4p
Description	RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
GO Terms: Biological Process	level 5: mRNA processing level 6: maturation of 5.8S rRNA level 6: RNA catabolic process level 7: poly(A)-dependent snoRNA 3'-end processing level 7: U4 snRNA 3'-end processing level 7: U5 snRNA 3'-end processing level 7: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) level 7: rRNA catabolic process level 7: nuclear polyadenylation-dependent mRNA catabolic process level 9: nuclear mRNA surveillance level 9: nuclear polyadenylation-dependent rRNA catabolic process level 9: TRAMP-dependent tRNA surveillance pathway level 10: nuclear mRNA surveillance of mRNA 3'-end processing
GO Terms: Molecular Function	level 1: catalytic activity level 2: ATP hydrolysis activity level 2: nucleic acid binding level 2: oxidoreductase activity level 3: RNA helicase activity level 3: RNA binding level 4: mRNA binding level 4: 3'-5' RNA helicase activity level 4: ATP binding level 6: poly(A) binding
GO Terms: Cellular Component	level 3: TRAMP complex level 4: nucleus level 4: nucleolus
External source	Open in SGD