S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Nuc1p
Description	Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG
GO Terms: Biological Process	level 4: apoptotic process level 4: defense response to virus level 5: apoptotic DNA fragmentation level 5: mitophagy level 6: DNA recombination level 6: RNA catabolic process level 6: DNA catabolic process level 7: regulation of mitochondrial DNA metabolic process
GO Terms: Molecular Function	level 2: nucleic acid binding level 2: hydrolase activity level 3: hydrolase activity, acting on ester bonds level 4: RNA nuclease activity level 5: DNA endonuclease activity level 5: RNA endonuclease activity level 5: DNA exonuclease activity level 5: metal ion binding
GO Terms: Cellular Component	level 2: cytosol level 3: mitochondrion level 4: nucleus level 4: mitochondrial inner membrane
External source	Open in SGD