S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Cbf1p
Description	Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress
GO Terms: Biological Process	level 3: chromosome segregation level 5: chromatin remodeling level 5: cellular response to methionine level 6: positive regulation of sulfate assimilation level 7: negative regulation of ceramide biosynthetic process level 8: positive regulation of inositol biosynthetic process level 8: double-strand break repair via break-induced replication level 9: regulation of transcription by RNA polymerase II level 10: negative regulation of transcription by RNA polymerase II level 10: positive regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 2: DNA-binding transcription factor activity level 3: protein dimerization activity level 4: DNA-binding transcription repressor activity, RNA polymerase II-specific level 4: DNA-binding transcription activator activity, RNA polymerase II-specific level 5: RNA polymerase II-specific DNA-binding transcription factor binding level 6: centromeric DNA binding level 6: RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO Terms: Cellular Component	level 3: mitochondrion level 3: chromosome, centromeric region level 3: kinetochore level 3: Cbf1-Met4-Met28 complex level 4: nucleus
External source	Open in SGD