S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Sod1p
Description	Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex
GO Terms: Biological Process	level 2: cellular detoxification level 4: fungal-type cell wall organization level 4: cellular response to oxidative stress level 4: protein stabilization level 4: superoxide metabolic process level 4: intracellular zinc ion homeostasis level 4: removal of superoxide radicals level 5: intracellular copper ion homeostasis level 6: negative regulation of cellular respiration level 10: positive regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 2: superoxide dismutase activity level 4: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor level 5: metal ion binding level 7: zinc ion binding level 7: copper ion binding
GO Terms: Cellular Component	level 2: cytoplasm level 2: cytosol level 3: mitochondrion level 4: nucleus level 4: mitochondrial intermembrane space
External source	Open in SGD