S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ctk1p
Description	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
GO Terms: Biological Process	level 3: translational initiation level 4: positive regulation of translational fidelity level 4: regulation of cell cycle level 6: mRNA 3'-end processing level 8: regulation of DNA-templated transcription level 10: positive regulation of DNA-templated transcription, elongation level 10: positive regulation of transcription by RNA polymerase I level 11: positive regulation of transcription elongation by RNA polymerase II
GO Terms: Molecular Function	level 3: protein kinase activity level 4: ATP binding level 4: RNA polymerase II CTD heptapeptide repeat kinase activity level 5: cyclin-dependent protein serine/threonine kinase activity
GO Terms: Cellular Component	level 2: nucleoplasm level 2: cytoplasm level 4: nucleus level 4: nucleolus level 4: cyclin/CDK positive transcription elongation factor complex level 5: CTDK-1 complex level 7: cyclin-dependent protein kinase holoenzyme complex
External source	Open in SGD