S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Gcn3p
Description	Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant
GO Terms: Biological Process	level 3: translational initiation level 5: positive regulation of cellular response to heat level 5: positive regulation of cellular response to amino acid starvation level 8: regulation of translational initiation level 9: positive regulation of translational initiation
GO Terms: Molecular Function	level 2: enzyme regulator activity level 2: translation initiation factor activity level 5: guanyl-nucleotide exchange factor activity
GO Terms: Cellular Component	level 2: cytosol level 3: eukaryotic translation initiation factor 2B complex level 3: guanyl-nucleotide exchange factor complex
External source	Open in SGD