S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hsp104p
Description	Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responds to stresses including heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation
GO Terms: Biological Process	level 2: protein unfolding level 2: protein folding level 3: protein transmembrane transport level 3: protein folding in endoplasmic reticulum level 3: protein refolding level 4: cellular response to heat level 5: cellular heat acclimation level 6: cytoplasmic stress granule disassembly level 7: trehalose metabolic process
GO Terms: Molecular Function	level 2: ATP hydrolysis activity level 2: ATP-dependent protein disaggregase activity level 3: identical protein binding level 3: protein-folding chaperone binding level 3: protein-transporting ATPase activity level 4: ATP binding level 5: ADP binding
GO Terms: Cellular Component	level 2: nuclear periphery level 2: cytoplasm level 2: cytosol level 3: TRC complex level 4: nucleus level 4: intracellular organelle lumen
External source	Open in SGD