Yeastract
YEASTRACT+ INESC-ID IST IBB
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Gene Ontology Information

Protein Name Hmg1p
Description HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant
GO Terms:
Biological Process		 level 4: coenzyme A metabolic process external link
level 5: isoprenoid biosynthetic process external link
level 7: ergosterol biosynthetic process external link
GO Terms:
Molecular Function		 level 4: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor external link
level 5: hydroxymethylglutaryl-CoA reductase (NADPH) activity external link
GO Terms:
Cellular Component		 level 2: nuclear periphery external link
level 2: cytosol external link
level 3: nuclear envelope external link
level 4: endoplasmic reticulum membrane external link
level 5: peroxisomal membrane external link
External source Open in SGD external link