S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ndi1p
Description	NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy
GO Terms: Biological Process	level 4: energy derivation by oxidation of organic compounds level 6: aerobic electron transport chain level 6: positive regulation of apoptotic process level 7: mitochondrial electron transport, NADH to ubiquinone
GO Terms: Molecular Function	level 2: oxidoreductase activity level 4: NADH dehydrogenase activity level 5: NADH dehydrogenase (quinone) (non-electrogenic) activity level 6: NADH dehydrogenase (ubiquinone) (non-electrogenic) activity
GO Terms: Cellular Component	level 2: cytosol level 3: mitochondrion level 4: mitochondrial inner membrane level 4: mitochondrial matrix
External source	Open in SGD