S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Mre11p
Description	Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
GO Terms: Biological Process	level 2: meiotic cell cycle level 3: ascospore formation level 3: reciprocal meiotic recombination level 4: meiotic DNA double-strand break formation level 5: DNA repair level 5: mitotic intra-S DNA damage checkpoint signaling level 5: mitotic G2 DNA damage checkpoint signaling level 6: telomere maintenance level 6: base-excision repair level 6: double-strand break repair level 7: double-strand break repair via homologous recombination level 7: mitochondrial double-strand break repair via homologous recombination level 7: double-strand break repair via nonhomologous end joining level 7: maintenance of DNA trinucleotide repeats level 7: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing level 8: double-strand break repair via break-induced replication level 9: regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 1: molecular adaptor activity level 2: hydrolase activity level 4: G-quadruplex DNA binding level 4: endonuclease activity level 4: single-stranded DNA endonuclease activity level 5: double-stranded telomeric DNA binding level 5: DNA endonuclease activity level 5: telomeric repeat DNA binding level 5: 3'-5' exonuclease activity level 6: AMP kinase activity level 6: 3'-5'-DNA exonuclease activity level 6: single-stranded telomeric DNA binding level 7: manganese ion binding
GO Terms: Cellular Component	level 3: Mre11 complex level 3: chromosome, telomeric region level 3: site of double-strand break level 3: mitochondrion level 4: nucleus level 4: chromosome
External source	Open in SGD