S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Top1p
Description	Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation
GO Terms: Biological Process	level 3: chromosome segregation level 4: chromatin organization level 4: mitotic chromosome condensation level 4: nuclear migration level 5: chromatin remodeling level 6: DNA replication level 6: chromosome condensation level 6: DNA topological change level 6: rDNA heterochromatin formation level 7: rRNA transcription level 7: DNA strand elongation involved in DNA replication level 8: transcription elongation by RNA polymerase II level 8: regulation of mitotic recombination level 9: regulation of transcription by RNA polymerase II
GO Terms: Molecular Function	level 3: DNA binding level 5: DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO Terms: Cellular Component	level 2: nucleoplasm level 2: cytoplasm level 3: mitochondrion level 4: nucleus level 4: chromosome level 4: nucleolus
External source	Open in SGD