S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hst1p
Description	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication
GO Terms: Biological Process	level 4: DNA damage response level 7: silent mating-type cassette heterochromatin formation level 7: subtelomeric heterochromatin formation level 8: negative regulation of DNA recombination level 9: negative regulation of DNA-templated transcription level 9: negative regulation of mitotic recombination
GO Terms: Molecular Function	level 3: transcription corepressor activity level 4: NAD-dependent protein lysine deacetylase activity level 5: NAD+ binding level 5: histone deacetylase activity, NAD-dependent level 6: histone H4K16 deacetylase activity, NAD-dependent level 6: histone H3K14 deacetylase activity, NAD-dependent level 6: histone H3K9 deacetylase activity, NAD-dependent level 7: zinc ion binding
GO Terms: Cellular Component	level 2: chromatin level 3: chromosome, telomeric region level 3: Set3 complex level 4: nucleus level 5: nuclear lumen
External source	Open in SGD