S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Hrt1p
Description	RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair
GO Terms: Biological Process	level 4: G1/S transition of mitotic cell cycle level 6: proteasomal protein catabolic process level 7: ubiquitin-dependent protein catabolic process level 8: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process level 9: protein ubiquitination
GO Terms: Molecular Function	level 2: protein-macromolecule adaptor activity level 3: cullin family protein binding level 4: ubiquitin-protein transferase activity level 5: ubiquitin protein ligase activity level 7: zinc ion binding
GO Terms: Cellular Component	level 2: cytoplasm level 3: chromosome, telomeric region level 4: cullin-RING ubiquitin ligase complex level 4: nucleus level 5: Cul3-RING ubiquitin ligase complex level 5: Cul8-RING ubiquitin ligase complex level 5: SCF ubiquitin ligase complex
External source	Open in SGD