S.cerevisiae - Yeastract

Gene Ontology Information

Protein Name	Ipl1p
Description	Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest
GO Terms: Biological Process	level 3: chromosome segregation level 3: attachment of spindle microtubules to kinetochore level 3: meiotic spindle checkpoint signaling level 4: mitotic DNA integrity checkpoint signaling level 4: homologous chromosome segregation level 4: meiotic sister chromatid segregation level 4: mitotic spindle disassembly level 4: mitotic spindle organization level 5: regulation of cytokinesis level 5: regulation of organelle assembly level 5: sister chromatid segregation level 7: regulation of mitotic cell cycle spindle assembly checkpoint level 7: regulation of mitotic spindle assembly level 7: response to mitotic cell cycle spindle assembly checkpoint signaling level 8: negative regulation of protein import into nucleus during spindle assembly checkpoint
GO Terms: Molecular Function	level 3: protein kinase activity level 4: protein serine kinase activity level 4: protein serine/threonine kinase activity level 4: ATP binding
GO Terms: Cellular Component	level 2: cytoplasm level 2: spindle midzone level 2: spindle pole level 3: chromosome passenger complex level 3: kinetochore level 4: nucleus level 4: spindle level 5: spindle microtubule level 6: kinetochore microtubule level 6: microtubule
External source	Open in SGD