Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
SIR3 Systematic Name
YLR442C Alias
CMT1, MAR2, STE8 Strain
S288c Description
Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>SIR3 YLR442C
ATGGCTAAAACATTGAAAGATTTGGACGGTTGGCAAGTTATCATTACAGATGATCAGGGG
AGGGTTATTGACGACAACAATAGAAGAAGATCAAGAAAAAGAGGAGGAGAAAACGTATTT
CTGAAAAGAATTTCTGATGGATTGAGTTTTGGGAAGGGTGAGAGCGTGATATTTAATGAT
AATGTGACGGAAACATATTCTGTCTACTTGATCCATGAGATCAGACTCAATACACTTAAT
AATGTTGTGGAGATTTGGGTTTTTTCTTACTTGAGATGGTTTGAACTCAAACCAAAACTG
TACTACGAACAATTCAGGCCAGATCTAATAAAGGAAGATCATCCTTTAGAATTTTACAAA
GATAAATTTTTCAACGAAGTAAATAAGAGCGAGTTATATTTAACTGCTGAGCTATCAGAG
ATTTGGCTTAAGGATTTCATTGCAGTTGGACAGATACTGCCAGAGTCACAATGGAATGAT
AGTAGTATCGATAAAATAGAGGATAGAGATTTTCTAGTACGTTATGCATGCGAACCTACT
GCGGAAAAGTTTGTACCAATTGATATTTTTCAAATCATAAGAAGAGTAAAGGAAATGGAA
CCCAAACAATCTGATGAATACTTGAAAAGAGTATCTGTACCAGTGAGTGGGCAGAAGACA
AATAGACAGGTGATGCATAAGATGGGAGTTGAAAGATCTTCAAAAAGACTAGCAAAGAAA
CCTTCAATGAAAAAAATTAAAATCGAGCCCTCTGCAGATGATGACGTAAATAATGGAAAT
ATACCGTCTCAGCGAGGAACGTCAACAACTCATGGTTCAATTTCTCCCCAAGAAGAGTCT
GTTTCCCCTAACATCTCATCGGCGTCCCCTTCTGCGCTCACATCACCTACAGATTCTTCG
AAAATTTTACAAAAAAGATCTATATCAAAGGAACTAATTGTTTCAGAGGAAATACCAATA
AACTCTTCAGAACAGGAATCCGATTATGAGCCAAACAATGAAACATCTGTGCTTTCAAGT
AAACCTGGGTCAAAGCCAGAGAAGACATCTACAGAACTCGTTGACGGCCGAGAGAATTTT
GTATATGCAAATAATCCAGAAGTGAGTGATGATGGTGGGCTTGAAGAGGAAACAGATGAA
GTTAGTTCAGAAAGTTCTGATGAAGCAATAATACCAGTAAATAAAAGACGTGGCGCTCAC
GGAAGCGAATTGAGCAGTAAAATTAGAAAAATCCACATTCAAGAAACACAAGAATTTTCT
AAAAATTACACTACAGAAACAGATAACGAAATGAACGGAAATGGAAAACCTGGAATTCCC
AGGGGCAACACCAAAATTCATAGTATGAACGAAAATCCTACACCAGAAAAAGGTAATGCA
AAGATGATTGATTTCGCTACTTTGTCAAAGTTGAAAAAAAAATATCAGATAATTTTAGAC
CGGTTTGCACCAGATAATCAAGTAACAGATTCCTCCCAATTGAACAAATTAACAGACGAA
CAGTCAAGCTTGGACGTTGCAGGCCTTGAGGATAAGTTTAGAAAAGCATGCTCTTCATCT
GGAAGAGAAACCATTCTGTCAAATTTTAACGCTGATATAAATTTAGAGGAATCAATTAGA
GAATCTTTACAAAAGAGAGAACTACTAAAATCACAAGTGGAGGATTTTACAAGAATATTC
CTTCCGATTTACGACAGTTTGATGTCTTCCCAAAATAAACTATTTTATATTACCAATGCA
GATGATTCTACTAAATTCCAGCTTGTGAATGATGTAATGGATGAGTTGATCACCTCTTCG
GCCCGAAAGGAACTACCTATTTTCGATTACATTCATATTGATGCCTTGGAACTGGCAGGA
ATGGATGCATTATATGAGAAAATATGGTTCGCCATTTCTAAAGAAAATCTATGCGGTGAT
ATATCACTAGAGGCCTTAAACTTCTATATTACAAATGTCCCGAAAGCAAAAAAGAGAAAG
ACACTAATATTAATACAAAATCCGGAAAATCTATTGAGTGAGAAGATTTTACAATATTTC
GAGAAATGGATTTCTTCGAAAAATTCAAAATTGTCTATCATTTGCGTTGGCGGACATAAT
GTGACGATTAGAGAGCAAATAAATATAATGCCCTCCCTCAAAGCACACTTTACCGAAATC
AAACTTAATAAGGTGGACAAGAATGAATTGCAACAAATGATCATCACGCGACTCAAATCT
TTATTGAAACCTTTTCATGTCAAAGTAAATGATAAGAAGGAAATGACTATTTACAATAAT
ATTCGCGAAGGACAGAACCAGAAAATACCAGATAATGTGATAGTAATCAATCATAAGATC
AACAACAAAATCACTCAACTTATTGCAAAGAACGTAGCCAACGTAAGTGGTAGTACTGAA
AAAGCATTCAAAATATGTGAAGCTGCCGTAGAAATTTCTAAAAAAGACTTCGTACGGAAA
GGTGGTCTACAAAAGGGTAAATTGGTAGTGTCACAGGAGATGGTACCACGCTATTTCTCA
GAAGCTATTAACGGATTCAAGGATGAAACTATTTCAAAGAAGATTATAGGAATGTCTCTG
TTGATGAGAACATTTTTATATACCCTGGCGCAAGAAACCGAAGGCACGAATCGTCATACG
CTTGCTCTGGAGACCGTCCTGATTAAGATGGTGAAGATGTTGCGGGACAACCCAGGGTAC
AAGGCGTCAAAAGAAATTAAGAAGGTCATATGCGGTGCCTGGGAGCCCGCAATAACTATA
GAGAAACTAAAGCAATTTTCTTGGATAAGTGTAGTGAATGATTTAGTGGGAGAAAAATTA
GTTGTTGTGGTGCTCGAGGAGCCCAGTGCAAGCATTATGGTAGAACTAAAACTTCCTTTA
GAAATAAATTACGCCTTTTCGATGGATGAAGAATTCAAAAATATGGACTGCATTTGA Promoter Sequence
Download FASTA
>SIR3 YLR442C
GAGTAAATGTAACACGTTGGCCTTTTTATGTTTTAAACTCCTCATGTAGGTCGTGTATGC
AGAACTTTCTGCCTGTTGTGAACCGATTTTGTTGTATGCATAATCTAAAATGATATCTAA
ACCCAAGCTTTCTAAAACCTCACGATAATCAAAAAGATAGTCCGTTCCTATGCTACTGCA
GGTACTCTTAGTAGTCGAATTCTTTACGCTATGCATATTTCCTTCAGAGTCGAATACTTC
CACCATGGTATATGTTGAATCGCACCTCCCATAAAGCGACACTGTGATGTACTGAGGAAC
ATTCTTTATCTGACTTTCGGTGTAAGCAGTCAATATATACAGTTCGGATGTTGTTAAGCC
TACACCGTTATTTTCTTCTGTAGATGTCGACTGCTCCATAGACTCTCTCAACACGGTAAA
TAAACCCGTCGTAATATCAGCAGAGTAAGTATCCAGTCGTGACATGTACAATGTTCTTGG
CGAAGAAAGGGGTCCGACAGTCAACGCCAACCCGAAAGAGATTATGAGTAATGTCGTCCC
TAATCTTAGCCACTGTACCACTTTCTCAAGGGCTGTAAGGTTCTGGAATGGCCTGGCTAT
TGTATCTCGTATTCTTGACATCACCATTTATTTTCGATCCATTAGATATGCAAGGGTATT
CGCAATGACTGATACACAAAGAAATGGTGTAAATGAAACTAAGTAGAGAGTTGACAGTGT
TAAGCAAACAACGAATCCAGGGGAACAAAGTATTCGGGACGTTTGTTTATGCGGCGTCCA
AAAGATGTATTTAAAGTTAACCATATTATGTATCAATCTAAATAAAGAAATAATTGTAAA
TTTTCATCGCATCAGTAATATGACCGCGAAAACGCTATTCTTTCCAAAAAAGTTAAAATG
AACATAGTATGAAAAAGAAAAACACATAAGCAGCCCTTTCATCACCTTCCTTACAGGGGT
TTAAGAAAGTTGTTTTGTTCTAACAATTGGATTAGCTAAA
Chr coordinates
Chr XII from 1022251-1019315
