S.cerevisiae - Yeastract

Regulation Reference(s)

The Yeastract team, is actively curating each regulation evidence code, association type and environmental condition.

Transcription Factor	Target ORF/Genes	References	Evidence Code	Evidence Experiment	Association Type	Strain	Environmental Group	Environmental Condition	Log2FC
Rox1p	YPR065W	PubMed Deckert J et al., Molecular and cellular biology, 1995 Nov;15(11):6109-17	N/A		N/A	S288c	N/A	N/A	N/A
		PubMed Deckert J et al., Genetics, 1995 Mar;139(3):1149-58	Indirect	lacZ - wt vs TF mutant	Negative	S288c	Oxygen availability	Anaerobiosis	N/A
		PubMed Harbison CT et al., Nature, 2004 Sep 2;431(7004):99-104	Direct	Chip-on-chip	N/A	S288c	N/A	N/A	N/A
		PubMed Chua G et al., Proceedings of the National Academy of Sciences of the United States of America, 2006 Aug 8;103(32):12045-50	Indirect	Microarray analysis - wt vs TF overexpression	Positive	N/A	Carbon source quality/availability	Cells grown in selective medium supplemented with 2% raffinose before induction with 2% galactose for 3 h	N/A
		PubMed Kelley R et al., PLoS genetics, 2009 May;5(5):e1000488	Indirect	Microarray analysis - wt vs TF mutant	Positive	BY4741	Stress	YPD 30.C 0.1 mM H2O2	N/A
		PubMed Castro-Prego R et al., The Biochemical journal, 2009 Dec 14;425(1):235-43	Direct	ChIP	N/A	S288c	Oxygen availability	Hypoxia	N/A
		PubMed Reimand J et al., Nucleic acids research, 2010 Aug;38(14):4768-77	Indirect	Microarray analysis - WT vs TF Deletion	Positive	BY4741; S288C; R1158	Unstressed log-phase growth (control)	Standard YPD conditions Dataset ewxtracted from The Longhorn Array Database (LAD). Transcription factor gene deletion.	0.38227227009137
		PubMed Huebert DJ et al., Molecular and cellular biology, 2012 May;32(9):1645-53	Indirect	RT-PCR - wt vs TF mutant	Negative	S288c	Unstressed log-phase growth (control)	Normoxia	N/A
		PubMed Rossi MJ et al., Nature, 2021 Apr;592(7853):309-314	Direct	ChIP-exo	N/A	BY4741	Unstressed log-phase growth (control)	YPD medium, 25.C	N/A
		PubMed Horkai D et al., PLoS biology, 2023 Aug;21(8):e3002245	Indirect	RNA-seq analysis - WT vs TF Deletion	Positive	MEP	Carbon source quality/availability	YPD,48h: Cells were grown in YP + 2% glucose (YPD) at 30°C, 200 rpm and mother cells were harvested 48h after estradiol addition (added at 2h post-inoculation).	9.139802
			Indirect	RNA-seq analysis - WT vs TF Deletion	Positive	MEP	Unstressed log-phase growth (control)	YPD,log: Cells were grown in YP + 2% glucose (YPD) at 30°C, 200 rpm and harvested at log phase as a young control.	12.707968
		PubMed van der Horst SC et al., Nature communications, 2025 Feb 6;16(1):1416	Indirect	RNA-seq analysis - WT vs TF Deletion	Positive	W303	Cell cycle/morphology	0 min: RNA-seq performed in YPAD medium. Overnight cultures were diluted in fresh YPAD and grown for 3 h. Cells were then synchronized in G1 by α-factor treatment for 2 h, washed once in YPAD, and released into YPAD containing 200 mM hydroxyurea (HU). Samples were collected at t=0min: immediately after α-factor synchronization (pre-HU release)	13.344946
			Indirect	RNA-seq analysis - WT vs TF Deletion	Positive	W303	Cell cycle/morphology	60 min: RNA-seq performed in YPAD medium. Overnight cultures were diluted in fresh YPAD and grown for 3 h. Cells were then synchronized in G1 by α-factor treatment for 2 h, washed once in YPAD, and released into YPAD containing 200 mM hydroxyurea (HU). Samples were collected at t=60min: 60 min after release into HU (replication stress condition)	15.166204